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Showing 1 to 12 of 334 entries
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An informatics search for the low-molecular weight chromium-binding peptide.

BMC chemical biology

Dinakarpandian D, Morrissette V, Chaudhary S, Amini K, Bennett B, Van Horn JD.
PMID: 15603587
BMC Chem Biol. 2004 Dec 16;4(1):2. doi: 10.1186/1472-6769-4-2.

BACKGROUND: The amino acid composition of a low molecular weight chromium binding peptide (LMWCr), isolated from bovine liver, is reportedly E:G:C:D::4:2:2:2, though its sequence has not been discovered. There is some controversy surrounding the exact biochemical forms and the...

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Dinakarpandian D, Morrissette V, Chaudhary S, et al. An informatics search for the low-molecular weight chromium-binding peptide. BMC Chem Biol. 2004;4(1):2doi: 10.1186/1472-6769-4-2.
Dinakarpandian, D., Morrissette, V., Chaudhary, S., Amini, K., Bennett, B., & Van Horn, J. D. (2004). An informatics search for the low-molecular weight chromium-binding peptide. BMC chemical biology, 4(1), 2. https://doi.org/10.1186/1472-6769-4-2
Dinakarpandian, Deendayal, et al. "An informatics search for the low-molecular weight chromium-binding peptide." BMC chemical biology vol. 4,1 (2004): 2. doi: https://doi.org/10.1186/1472-6769-4-2
Dinakarpandian D, Morrissette V, Chaudhary S, Amini K, Bennett B, Van Horn JD. An informatics search for the low-molecular weight chromium-binding peptide. BMC Chem Biol. 2004 Dec 16;4(1):2. doi: 10.1186/1472-6769-4-2. PMID: 15603587; PMCID: PMC539358.
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Studies on the synthesis, characterization, binding with DNA and activities of two cis-planaramineplatinum(II) complexes of the form: cis-PtL(NH3)Cl2 where L = 3-hydroxypyridine and 2,3-diaminopyridine.

BMC chemical biology

Abdullah A, Huq F, Chowdhury A, Tayyem H, Beale P, Fisher K.
PMID: 16533399
BMC Chem Biol. 2006 Mar 13;6:3. doi: 10.1186/1472-6769-6-3.

BACKGROUND: Cis-planaramineplatinum(II) complexes like their trans isomers are often found to be active against cancer cell lines. The present study deals with the synthesis, characterization and determination of activity of new cis-planaramineplatinum(II) complexes.RESULTS: Two cis-planaramineplatinum(II) complexes: cis-(3-hydroxypyridine)(ammine)dichloroplatinum(II) (code named...

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Abdullah A, Huq F, Chowdhury A, et al. Studies on the synthesis, characterization, binding with DNA and activities of two cis-planaramineplatinum(II) complexes of the form: cis-PtL(NH3)Cl2 where L = 3-hydroxypyridine and 2,3-diaminopyridine. BMC Chem Biol. 2006;6:3doi: 10.1186/1472-6769-6-3.
Abdullah, A., Huq, F., Chowdhury, A., Tayyem, H., Beale, P., & Fisher, K. (2006). Studies on the synthesis, characterization, binding with DNA and activities of two cis-planaramineplatinum(II) complexes of the form: cis-PtL(NH3)Cl2 where L = 3-hydroxypyridine and 2,3-diaminopyridine. BMC chemical biology, 63. https://doi.org/10.1186/1472-6769-6-3
Abdullah, Ahmed, et al. "Studies on the synthesis, characterization, binding with DNA and activities of two cis-planaramineplatinum(II) complexes of the form: cis-PtL(NH3)Cl2 where L = 3-hydroxypyridine and 2,3-diaminopyridine." BMC chemical biology vol. 6 (2006): 3. doi: https://doi.org/10.1186/1472-6769-6-3
Abdullah A, Huq F, Chowdhury A, Tayyem H, Beale P, Fisher K. Studies on the synthesis, characterization, binding with DNA and activities of two cis-planaramineplatinum(II) complexes of the form: cis-PtL(NH3)Cl2 where L = 3-hydroxypyridine and 2,3-diaminopyridine. BMC Chem Biol. 2006 Mar 13;6:3. doi: 10.1186/1472-6769-6-3. PMID: 16533399; PMCID: PMC1431574.
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Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol.

BMC chemical biology

Maliga Z, Mitchison TJ.
PMID: 16504166
BMC Chem Biol. 2006 Feb 27;6:2. doi: 10.1186/1472-6769-6-2.

BACKGROUND: A recent crystal structure of monastrol in a ternary complex with the kinesin Eg5 motor domain highlights a novel, induced-fit drug binding site at atomic resolution. Mutational obliteration of the monastrol binding site results in a monastrol-resistant, but...

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Maliga Z, Mitchison TJ. Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol. BMC Chem Biol. 2006;6:2doi: 10.1186/1472-6769-6-2.
Maliga, Z., & Mitchison, T. J. (2006). Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol. BMC chemical biology, 62. https://doi.org/10.1186/1472-6769-6-2
Maliga, Zoltan, and Mitchison, Timothy J. "Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol." BMC chemical biology vol. 6 (2006): 2. doi: https://doi.org/10.1186/1472-6769-6-2
Maliga Z, Mitchison TJ. Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol. BMC Chem Biol. 2006 Feb 27;6:2. doi: 10.1186/1472-6769-6-2. PMID: 16504166; PMCID: PMC1448180.
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Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus.

BMC chemical biology

Pezacki JP, Sagan SM, Tonary AM, Rouleau Y, Bélanger S, Supekova L, Su AI.
PMID: 19149867
BMC Chem Biol. 2009 Jan 16;9:2. doi: 10.1186/1472-6769-9-2.

BACKGROUND: Hepatitis C virus (HCV) infection is a global health problem. A number of studies have implicated a direct role of cellular lipid metabolism in the HCV life cycle and inhibitors of the mevalonate pathway have been demonstrated to...

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Pezacki JP, Sagan SM, Tonary AM, et al. Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus. BMC Chem Biol. 2009;9:2doi: 10.1186/1472-6769-9-2.
Pezacki, J. P., Sagan, S. M., Tonary, A. M., Rouleau, Y., Bélanger, S., Supekova, L., & Su, A. I. (2009). Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus. BMC chemical biology, 92. https://doi.org/10.1186/1472-6769-9-2
Pezacki, John Paul, et al. "Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus." BMC chemical biology vol. 9 (2009): 2. doi: https://doi.org/10.1186/1472-6769-9-2
Pezacki JP, Sagan SM, Tonary AM, Rouleau Y, Bélanger S, Supekova L, Su AI. Transcriptional profiling of the effects of 25-hydroxycholesterol on human hepatocyte metabolism and the antiviral state it conveys against the hepatitis C virus. BMC Chem Biol. 2009 Jan 16;9:2. doi: 10.1186/1472-6769-9-2. PMID: 19149867; PMCID: PMC2651120.
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Enhancement of intracellular gamma-tocopherol levels in cytokine-stimulated C3H 10T1/2 fibroblasts: relation to NO synthesis, isoprostane formation, and tocopherol oxidation.

BMC chemical biology

Tanaka Y, Wood LA, Cooney RV.
PMID: 17608946
BMC Chem Biol. 2007 Jul 03;7:2. doi: 10.1186/1472-6769-7-2.

BACKGROUND: Stimulation of C3H 10T1/2 murine fibroblasts with interferon-gamma(IFN) and bacterial lipopolysaccharide (LPS) generates reactive oxygen and nitrogen species leading to DNA damage, lipid oxidation, and tocopherol oxidation. The tocopherols possess unique chemical and biological properties that suggest they...

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Tanaka Y, Wood LA, Cooney RV. Enhancement of intracellular gamma-tocopherol levels in cytokine-stimulated C3H 10T1/2 fibroblasts: relation to NO synthesis, isoprostane formation, and tocopherol oxidation. BMC Chem Biol. 2007;7:2doi: 10.1186/1472-6769-7-2.
Tanaka, Y., Wood, L. A., & Cooney, R. V. (2007). Enhancement of intracellular gamma-tocopherol levels in cytokine-stimulated C3H 10T1/2 fibroblasts: relation to NO synthesis, isoprostane formation, and tocopherol oxidation. BMC chemical biology, 72. https://doi.org/10.1186/1472-6769-7-2
Tanaka, Yuichiro, et al. "Enhancement of intracellular gamma-tocopherol levels in cytokine-stimulated C3H 10T1/2 fibroblasts: relation to NO synthesis, isoprostane formation, and tocopherol oxidation." BMC chemical biology vol. 7 (2007): 2. doi: https://doi.org/10.1186/1472-6769-7-2
Tanaka Y, Wood LA, Cooney RV. Enhancement of intracellular gamma-tocopherol levels in cytokine-stimulated C3H 10T1/2 fibroblasts: relation to NO synthesis, isoprostane formation, and tocopherol oxidation. BMC Chem Biol. 2007 Jul 03;7:2. doi: 10.1186/1472-6769-7-2. PMID: 17608946; PMCID: PMC1931582.
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Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue.

BMC chemical biology

Chène P, Rudloff J, Schoepfer J, Furet P, Meier P, Qian Z, Schlaeppi JM, Schmitz R, Radimerski T.
PMID: 19128485
BMC Chem Biol. 2009 Jan 07;9:1. doi: 10.1186/1472-6769-9-1.

BACKGROUND: Topoisomerase II poisons are in clinical use as anti-cancer therapy for decades and work by stabilizing the enzyme-induced DNA breaks. In contrast, catalytic inhibitors block the enzyme before DNA scission. Although several catalytic inhibitors of topoisomerase II have...

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Chène P, Rudloff J, Schoepfer J, et al. Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue. BMC Chem Biol. 2009;9:1doi: 10.1186/1472-6769-9-1.
Chène, P., Rudloff, J., Schoepfer, J., Furet, P., Meier, P., Qian, Z., Schlaeppi, J. M., Schmitz, R., & Radimerski, T. (2009). Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue. BMC chemical biology, 91. https://doi.org/10.1186/1472-6769-9-1
Chène, Patrick, et al. "Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue." BMC chemical biology vol. 9 (2009): 1. doi: https://doi.org/10.1186/1472-6769-9-1
Chène P, Rudloff J, Schoepfer J, Furet P, Meier P, Qian Z, Schlaeppi JM, Schmitz R, Radimerski T. Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue. BMC Chem Biol. 2009 Jan 07;9:1. doi: 10.1186/1472-6769-9-1. PMID: 19128485; PMCID: PMC2628638.
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DG-AMMOS: a new tool to generate 3d conformation of small molecules using distance geometry and automated molecular mechanics optimization for in silico screening.

BMC chemical biology

Lagorce D, Pencheva T, Villoutreix BO, Miteva MA.
PMID: 19912625
BMC Chem Biol. 2009 Nov 13;9:6. doi: 10.1186/1472-6769-9-6.

BACKGROUND: Discovery of new bioactive molecules that could enter drug discovery programs or that could serve as chemical probes is a very complex and costly endeavor. Structure-based and ligand-based in silico screening approaches are nowadays extensively used to complement...

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Lagorce D, Pencheva T, Villoutreix BO, et al. DG-AMMOS: a new tool to generate 3d conformation of small molecules using distance geometry and automated molecular mechanics optimization for in silico screening. BMC Chem Biol. 2009;9:6doi: 10.1186/1472-6769-9-6.
Lagorce, D., Pencheva, T., Villoutreix, B. O., & Miteva, M. A. (2009). DG-AMMOS: a new tool to generate 3d conformation of small molecules using distance geometry and automated molecular mechanics optimization for in silico screening. BMC chemical biology, 96. https://doi.org/10.1186/1472-6769-9-6
Lagorce, David, et al. "DG-AMMOS: a new tool to generate 3d conformation of small molecules using distance geometry and automated molecular mechanics optimization for in silico screening." BMC chemical biology vol. 9 (2009): 6. doi: https://doi.org/10.1186/1472-6769-9-6
Lagorce D, Pencheva T, Villoutreix BO, Miteva MA. DG-AMMOS: a new tool to generate 3d conformation of small molecules using distance geometry and automated molecular mechanics optimization for in silico screening. BMC Chem Biol. 2009 Nov 13;9:6. doi: 10.1186/1472-6769-9-6. PMID: 19912625; PMCID: PMC2781789.
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Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1.

BMC chemical biology

Xu FL, Rbaibi Y, Kiselyov K, Lazo JS, Wipf P, Saunders WS.
PMID: 20181182
BMC Chem Biol. 2010 Feb 11;10:1. doi: 10.1186/1472-6769-10-1.

BACKGROUND: Disorazoles are polyene macrodiolides isolated from a myxobacterium fermentation broth. Disorazole C1 was newly synthesized and found to depolymerize microtubules and cause mitotic arrest. Here we examined the cellular responses to disorazole C1 in both non-cancer and cancer...

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Xu FL, Rbaibi Y, Kiselyov K, et al. Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1. BMC Chem Biol. 2010;10:1doi: 10.1186/1472-6769-10-1.
Xu, F. L., Rbaibi, Y., Kiselyov, K., Lazo, J. S., Wipf, P., & Saunders, W. S. (2010). Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1. BMC chemical biology, 101. https://doi.org/10.1186/1472-6769-10-1
Xu, Fengfeng L, et al. "Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1." BMC chemical biology vol. 10 (2010): 1. doi: https://doi.org/10.1186/1472-6769-10-1
Xu FL, Rbaibi Y, Kiselyov K, Lazo JS, Wipf P, Saunders WS. Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1. BMC Chem Biol. 2010 Feb 11;10:1. doi: 10.1186/1472-6769-10-1. PMID: 20181182; PMCID: PMC2834648.
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Development of an HPLC method for determination of pentachloronitrobenzene, hexachlorobenzene and their possible metabolites.

BMC chemical biology

Khan F, Prakash D, Jain R.
PMID: 22112041
BMC Chem Biol. 2011 Nov 23;11:2. doi: 10.1186/1472-6769-11-2.

BACKGROUND: Pentachloronitrobenzene (PCNB) and hexachlorobenzene (HCB) are highly toxic and widespread in every environmental compartment. Some of metabolic products such as amino/nitro containing chlorinated aromatic compounds can be determined by gas chromatography coupled with electron capture detector (GC-ECD). However,...

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Khan F, Prakash D, Jain R. Development of an HPLC method for determination of pentachloronitrobenzene, hexachlorobenzene and their possible metabolites. BMC Chem Biol. 2011;11:2doi: 10.1186/1472-6769-11-2.
Khan, F., Prakash, D., & Jain, R. (2011). Development of an HPLC method for determination of pentachloronitrobenzene, hexachlorobenzene and their possible metabolites. BMC chemical biology, 112. https://doi.org/10.1186/1472-6769-11-2
Khan, Fazlurrahman, et al. "Development of an HPLC method for determination of pentachloronitrobenzene, hexachlorobenzene and their possible metabolites." BMC chemical biology vol. 11 (2011): 2. doi: https://doi.org/10.1186/1472-6769-11-2
Khan F, Prakash D, Jain R. Development of an HPLC method for determination of pentachloronitrobenzene, hexachlorobenzene and their possible metabolites. BMC Chem Biol. 2011 Nov 23;11:2. doi: 10.1186/1472-6769-11-2. PMID: 22112041; PMCID: PMC3341572.
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Identification Of Small Molecule TRABID Deubiquitinase Inhibitors By Computation-Based Virtual Screen.

BMC chemical biology

Shi T, Bao J, Wang NX, Zheng J, Wu D.
PMID: 22584113
BMC Chem Biol. 2012 May 14;12:4. doi: 10.1186/1472-6769-12-4.

BACKGROUND: Wnt/β-catenin-mediated gene transcription plays important roles in a wide range of biological and pathophysiological processes including tumorigenesis where β-catenin-mediated transcription activity frequently elevates. TRABID, a deubiquitinase, was shown to have a positive Wnt/β-catenin-mediated gene transcription and hence holds...

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Shi T, Bao J, Wang NX, et al. Identification Of Small Molecule TRABID Deubiquitinase Inhibitors By Computation-Based Virtual Screen. BMC Chem Biol. 2012;12:4doi: 10.1186/1472-6769-12-4.
Shi, T., Bao, J., Wang, N. X., Zheng, J., & Wu, D. (2012). Identification Of Small Molecule TRABID Deubiquitinase Inhibitors By Computation-Based Virtual Screen. BMC chemical biology, 124. https://doi.org/10.1186/1472-6769-12-4
Shi, Tong, et al. "Identification Of Small Molecule TRABID Deubiquitinase Inhibitors By Computation-Based Virtual Screen." BMC chemical biology vol. 12 (2012): 4. doi: https://doi.org/10.1186/1472-6769-12-4
Shi T, Bao J, Wang NX, Zheng J, Wu D. Identification Of Small Molecule TRABID Deubiquitinase Inhibitors By Computation-Based Virtual Screen. BMC Chem Biol. 2012 May 14;12:4. doi: 10.1186/1472-6769-12-4. PMID: 22584113; PMCID: PMC3475094.
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Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental verifications.

BMC chemical biology

Kobayashi H, Harada H, Nakamura M, Futamura Y, Ito A, Yoshida M, Iemura SI, Shin-Ya K, Doi T, Takahashi T, Natsume T, Imoto M, Sakakibara Y.
PMID: 22480302
BMC Chem Biol. 2012 Apr 05;12:2. doi: 10.1186/1472-6769-12-2.

BACKGROUND: Identification of the target proteins of bioactive compounds is critical for elucidating the mode of action; however, target identification has been difficult in general, mostly due to the low sensitivity of detection using affinity chromatography followed by CBB...

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Kobayashi H, Harada H, Nakamura M, et al. Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental verifications. BMC Chem Biol. 2012;12:2doi: 10.1186/1472-6769-12-2.
Kobayashi, H., Harada, H., Nakamura, M., Futamura, Y., Ito, A., Yoshida, M., Iemura, S. I., Shin-Ya, K., Doi, T., Takahashi, T., Natsume, T., Imoto, M., & Sakakibara, Y. (2012). Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental verifications. BMC chemical biology, 122. https://doi.org/10.1186/1472-6769-12-2
Kobayashi, Hiroki, et al. "Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental verifications." BMC chemical biology vol. 12 (2012): 2. doi: https://doi.org/10.1186/1472-6769-12-2
Kobayashi H, Harada H, Nakamura M, Futamura Y, Ito A, Yoshida M, Iemura SI, Shin-Ya K, Doi T, Takahashi T, Natsume T, Imoto M, Sakakibara Y. Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental verifications. BMC Chem Biol. 2012 Apr 05;12:2. doi: 10.1186/1472-6769-12-2. PMID: 22480302; PMCID: PMC3471015.
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Three smart spectrophotometric methods for resolution of severely overlapped binary mixture of Ibuprofen and Paracetamol in pharmaceutical dosage form.

BMC chemistry

El-Maraghy CM, Lamie NT.
PMID: 31406964
BMC Chem. 2019 Aug 06;13(1):99. doi: 10.1186/s13065-019-0618-3. eCollection 2019 Dec.

Paracetamol is an analgesic-antipyretic drug and Ibuprofen is a non-steroidal anti-inflammatory drug. They are co-formulated as tablets to improve analgesia, to simplify prescribing and to improve patient compliance. Three accurate, simple and sensitive spectrophotometric methods were developed for the...

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El-Maraghy CM, Lamie NT. Three smart spectrophotometric methods for resolution of severely overlapped binary mixture of Ibuprofen and Paracetamol in pharmaceutical dosage form. BMC Chem. 2019;13(1):99doi: 10.1186/s13065-019-0618-3.
El-Maraghy, C. M., & Lamie, N. T. (2019). Three smart spectrophotometric methods for resolution of severely overlapped binary mixture of Ibuprofen and Paracetamol in pharmaceutical dosage form. BMC chemistry, 13(1), 99. https://doi.org/10.1186/s13065-019-0618-3
El-Maraghy, Christine M, and Lamie, Nesrine T. "Three smart spectrophotometric methods for resolution of severely overlapped binary mixture of Ibuprofen and Paracetamol in pharmaceutical dosage form." BMC chemistry vol. 13,1 (2019): 99. doi: https://doi.org/10.1186/s13065-019-0618-3
El-Maraghy CM, Lamie NT. Three smart spectrophotometric methods for resolution of severely overlapped binary mixture of Ibuprofen and Paracetamol in pharmaceutical dosage form. BMC Chem. 2019 Aug 06;13(1):99. doi: 10.1186/s13065-019-0618-3. eCollection 2019 Dec. PMID: 31406964; PMCID: PMC6683492.
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Showing 1 to 12 of 334 entries